NLM Copyright © 2013 The Authors. | Learn more. Several photo-caged alcohols were synthesized via mild copper(II)-catalyzed substitution between tertiary propargylic alcohols and 2-nitrobenzyl alcohol to build up robust, base stable o-nitrobenzyl (NB) photo-cleavable compounds. 2016 Sep 21;27(9):2149-56. doi: 10.1021/acs.bioconjchem.6b00368. Nucleosides Nucleotides Nucleic Acids. and you may need to create a new Wiley Online Library account. Please check your email for instructions on resetting your password. Kupryushkin MS, Konevetz DA, Vasilyeva SV, Kuznetsova AS, Stetsenko DA, Pyshnyi DV. 2013. eg. 1:56 PM 4. Following early reports on PPGs for use in organic … Copyright © 2017 Elsevier Ltd. All rights reserved. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. The azide can be used for a “click” reaction and the TIPS group can be removed following polymerization, allowing the alkyne … Conjugatable and Bioreduction Cleavable Linker for the 5'-Functionalization of Oligonucleotides. Copyright © 2020 Elsevier B.V. or its licensors or contributors. Photoremovable (sometimes called photoreleasable, photocleavable or photoactivatable) protecting groups (PPGs) provide spatial and temporal control over the release of various chemicals such as bioagents (neurotransmitters and cell-signaling molecules), acids, bases, Ca 2+ ions, oxidants, insecticides, pheromones, fragrances, etc. Get the latest research from NIH: https://www.nih.gov/coronavirus. | We use cookies to help provide and enhance our service and tailor content and ads. Published by Elsevier Ltd. https://doi.org/10.1016/j.tetlet.2013.07.144. Mechanism of CB1954 reduction by Escherichia coli nitroreductase. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. A photolabile protection strategy for terminal alkynes. Number of times cited according to CrossRef: Synthesis of Terminal Ethynyl Aryl Selenides and Sulfides Based on the Retro‐Favorskii Reaction of Hydroxypropargyl Precursors. The alkyne group could also be used as an affinity tag for the lipids by a catch-and-release strategy on phosphine-coated silica beads. Subsequently, controlled pore glass-supported oligonucleotides were conjugated to a variety of functional molecules using a copper-catalyzed azide-alkyne cycloaddition reaction. Protection of an acetylenic hydrogen is often necessary because of its acidity. TMS as an alkyne protecting group is not satisfactory, the TIPS group is a valid alternative and its removal can be efficiently accomplished with stoichiometric AgF. 2: see also alkyl group, aryl group, alkenyl group Alkyne-linked reduction-activated protecting groups for diverse functionalization on the backbone of oligonucleotides. Protection of an acetylenic hydrogen is often necessary because of its acidity. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Nucleosides Nucleotides Nucleic Acids. If you do not receive an email within 10 minutes, your email address may not be registered, By continuing you agree to the use of cookies. Conjugation; Drug delivery; Oligonucleotide therapeutics; Protecting group. Saneyoshi H, Yamamoto Y, Kondo K, Hiyoshi Y, Ono A. J Org Chem. Keywords: 1: eg. 2018;66(2):147-154. doi: 10.1248/cpb.c17-00696. Use the link below to share a full-text version of this article with your friends and colleagues.
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